3-CYANOQUINOLIMES AS INHIBITORS OF EGF-R AND HER2 KINASES Russian patent published in 2007 - IPC C07D215/54 C07D401/12 A61K31/47 A61P35/00 

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to compounds of general formula I , wherein Z is -NH-; X is radical; E is phenyl optionally monosubstituted with halogen; T is -O(CH₂)_m-, -S(CH₂)_m-; L is phenyl etc.; G₁, G₂, G₃, and G₄ are independently hydrogen, C₁-C₆-alkoxy, R₂NH; R₇ is -J; M is >NR₆; W is direct bond; Het is pyrrolidine optionally monosubstituted at R₆, hydroxy; each R₆ is independently hydrogen, C₁-C₆-alkyl, C₂-C₆-alkenyl; R₂ is ; each R₃ is , etc; J are independently hydrogen, chlorine, bromine or iodine; a = 0 or 1; n = 0 or 1; M = 1; p = 2-4; r = 1-4; u = 4 and pharmaceutically acceptable salts thereof. Also disclosed are methods for treatment, growth inhibiting or combating of neoplasm and other disorders and pharmaceutical composition having activity of EGF-R and HER2 kinase inhibitors, as well as method for production of abovementioned compounds.

EFFECT: new compounds with useful biological properties.

31 cl, 3 tbl, 10 ex