FIELD: organic chemistry, biochemistry, pharmacy. SUBSTANCE: invention relates to substituted 3-cyanoquinolines of the formula (1) 
where R1, R2, R3, R4, X and Y are given in the invention claim. Invention describes also methods of synthesis of these compounds, methods of treatment and inhibition using these compounds and pharmaceutical composition based on thereof. Invention can be used in medicine for treatment of diseases that are result of disturbance of regulation of some receptor protein tyrosine kinases. EFFECT: improved method of synthesis and treatment, valuable medicinal properties of compounds. 47 cl, 14 tbl _
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Year |
Author |
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| QUINAZOLINE SUBSTITUTED DERIVATIVES |
1997 |
- Vissner Allan
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- Flojd Middlton Broner Ml.
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|
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1997 |
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1996 |
- Jurgen Kurttse
- Kristine Khelene Gertrud Rudol'F
- Ljudvig Shreder
- Gvido Al'Bert
- Anneroze Ehdit Ehlize Renig
- Ehval'D Gerkhard Ziverding
|
RU2129788C1 |
| METHOD FOR PRODUCTION OF 7-SUBSTITUTED-3-QUINOLINE AND 3-QUINOL-4-ON CARBONITRYLES |
2003 |
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- Berger Dehn Marten
|
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1993 |
|
RU2090558C1 |
| DERIVATIVES OF AMINOPHENYLKETONE AND METHOD OF THEIR SYNTHESIS |
1997 |
- Kortes Dehvid Andres
- Kremer Kennet Al'Fred Martin
|
RU2201418C2 |
| SYNTHESIS AND USAGE OF ORTHO-SULFONEAMIDO-BICYCLIC HETEROARYL HYDROXAMIC ACIDS AS INHIBITORS OF MATRIX METALLOPROTEINASES AND TACE (TNF-α-CONVERTING ENZYME) |
1998 |
- Levin Dzheremi Jan
- Zask Ari
- Gu Jansong
- Olbrajt Dzhej Donal'D
- Du Ksuemej
|
RU2202546C2 |
| METHOD OF PREPARING 2-PERFLUOROALKYL-3-OXAZOLIN-5-ONE, AND INTERMEDIATE PRODUCTS |
1994 |
|
RU2134262C1 |
| NEW 7-(SUBSTITUTED)-8-(SUBSTITUTED)-9-[(SUBSTITUTED-GLYCYL)- -AMIDO]-6-DEMETHYL-6-DEOXYTETRACYCLINES OR THEIR PHARMACEUTICALLY ACCEPTABLE SALTS OR COMPLEXES WITH METALS, METHODS OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION SHOWING ANTIBIOTIC ACTIVITY |
1993 |
- Fajk-Eng Sum
- Ving Dzh. Li
- Dzhozef Dzh. Khlavka
- Rajmond T. Testa
|
RU2125985C1 |
| SUSPENDED INSECTICIDE AND ACARICIDE CONCENTRATED COMPOSITIONS |
1995 |
- Krehjg Arlen Martin
- Mimi Jikh-Pej Chu Shaf
|
RU2147399C1 |
