NEW COMPOUNDS AS ANTI-INFLAMMATORY, IMMUNOMODULATING, AND ANTI-PROLIFERATIVE AGENTS Russian patent published in 2007 - IPC C07C233/60 C07C233/58 C07C233/59 C07C233/62 C07C255/60 C07D335/12 C07D333/38 C07D333/60 C07D307/30 A61K31/167 A61K31/341 A61K31/381 

FIELD: organic chemistry, pharmaceuticals.

SUBSTANCE: invention relates to compounds of general formula I and salt thereof, wherein F is non-aromatic ring system containing five carbon atoms and at least one double bond wherein one ring carbon atom is optionally substituted with X group, such as S, O, or SO₂, and one or more ring carbon atoms are optionally substituted with R¹; D represents S, O, SO₂, NR₄, or CH₂; Z¹ and Z² are independently O; Y is steryl, mono- or polycyclic non-substituted ring system, containing one or more X group such as S, O, SO₂, N; m, n, p, r and q = 0 or 1; meanings of the rest substituents are as defined in specification. Also invention relates to compounds of general formula I , wherein m, n, and q = 0; r = 1. Disclosed is pharmaceutical composition having inhibitory activity in relates to dihydroorotate dehydrogenase (DHODH) containing effective amount of said compound in free form or in form of pharmaceutically acceptable salts together with pharmaceutically acceptable diluents or carriers. Compounds of formula I are useful as drug inhibiting DHODH for treatment of disease or therapeutic condition in which inhibition of DHODH is beneficial.

EFFECT: new compounds as anti-inflammatory, immunomodulating, and anti-proliferative agents.

13 cl, 1 tbl, 1 dwg, 76 ex