FIELD: organic chemistry.
SUBSTANCE: invention relates to a heterocyclic compound of formula (I) or a pharmaceutically acceptable salt thereof, where Y represents CHR5 or NR6; Z is CH; n is 0 or 1; R1 is -OLN(R7)2 or a four-membered saturated N -heterocyclyl substituted with NMe 2; R 2 is C1-3 alkyl; each R3 is independently halogen; R4 is C1-6 alkyl; R5 is hydrogen, C1-3 alkyl or benzyloxy; R6 is C1-3 alkyl; each R7 is independently H or C1-3 alkyl; and L is ethylene. The invention also relates to specific compounds, a pharmaceutical composition based on a compound of formula (I) or specific compounds indicated, a method for treating cancer with the said compounds.
EFFECT: invention provides effective treatment of an oncological disease with a double inhibitor of ATM and DNA-PK.
39 cl, 9 dwg, 6 tbl, 6 ex
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