FIELD: chemistry; biochemistry.
SUBSTANCE: invention relates to compounds of general formula (II) and pharmaceutically acceptable salts thereof, and to use and a pharmaceutical composition based on the said compounds. In formula (II) 
compounds, A is a heteroaromatic 5-member cyclic system containing one group X selected from a group consisting of S and O; Z1 and Z2 independently represent O; R2 is OR6; R6 is H; R8 is hydrogen or (C1-C6)alkyl; E is phenyl which is optionally substituted with 1-4 substitutes in form of halogen; Y is phenyl which is optionally substituted with 1-2 substitutes selected from halogen, (C1-C6)alkoxy or halogen((C1-C6))alkyloxy; m equals 0; n equals 0; q equals 0; t equals 0; or pharmaceutically acceptable salts thereof.
EFFECT: obtaining aromatic compounds of formula (II) for inhibiting dehydroorotate dehydrogenase.
6 cl, 22 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SUBSTITUTED NICOTINAMIDES AS KCNQ2-3 MODULATORS | 2010 |
|
RU2529904C2 |
| METHOD OF PRODUCING OXAZOLES THROUGH CONDENSATION OF AROMATIC ALDEHYDES WITH ALPHA-KETOXIMES WITH FORMATION OF N-OXIDES AND SUBSEQUENT REACTION WITH ACTIVATED ACID DERIVATIVES | 2005 |
|
RU2402537C2 |
| TRPV1 ANTAGONISTS AND USE THEREOF | 2008 |
|
RU2452733C2 |
| DERIVATIVES OF BENZIMIDAZOL INHIBITING FACTOR Xa | 2004 |
|
RU2346944C2 |
| PHARMACOLOGICALLY ACTIVE COMPOUNDS AS INHIBITORS OF THE TAM FAMILY RECEPTOR TYROSINE KINASE | 2016 |
|
RU2750727C2 |
| SUBSTITUTED DERIVATIVES OF 1-OXA-2,8-DIAZASPIRO[4,5]DEC-2-ENE, METHOD FOR PRODUCTION THEREOF AND DRUG HAVING ANALGESIC ACTION | 2002 |
|
RU2296128C2 |
| SUBSTITUTED 2-OXO- AND 2- THIOXO- DIHYDROQUINOLINE-3-CARBOXAMIDES AS KCNQ2/3 MODULATORS | 2011 |
|
RU2581362C2 |
| 4-AMINOQUINAZOLINE ANTAGONISTS OF SELECTIVE SODIUM AND CALCIUM ION CHANNELS | 2004 |
|
RU2378260C2 |
| ACIDIFIED INDANYLAMINES AND THEIR USE AS PHARMACEUTICAL PREPARATIONS | 2002 |
|
RU2339614C2 |
| COMBINATION OF SPECIFIC OPIOIDS WITH MUSCARINE ANTAGONISTS FOR INCONTINENCE THERAPY | 2002 |
|
RU2305562C2 |
