FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for synthesis of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid of high purity from ethyl-(2,6-dichloro-5-fluoropyridine-3-yl)-3-oxopropanate and using a single solvent in one reaction vessel. Effective synthesis of 7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylc acid by this method is very significant in economical producing antibiotics based on fluoroquinolones used in treatment of microbial infections.
EFFECT: improved method of synthesis.
10 cl, 3 ex
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