FIELD: organic chemistry, medicine, oncology, biochemistry.
SUBSTANCE: invention relates to a method for preparing a combination comprising (a) cyclooxygenase 2 inhibitor (COX 2 inhibitor) chosen from a compound of the general formula (I): 
, and (b) histone deacetylase inhibitor chosen from N-hydroxy-3-[4-[[[2-(2-methyl-1H-indole-3-yl)ethyl]amino]methyl]phenyl-2E-2-propenamide for simultaneous, combined, separate of successive using. Proposed composition elicits the expressed synergistic effect in treatment of pretumor damages of colon or colon cancer or other malignant tumors in mammal, especially, in humans.
EFFECT: valuable medicinal properties of composition.
5 cl, 3 tbl, 5 ex
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