NOVEL COMPOUNDS AND COMPOSITIONS FOR INHIBITING NAMPT Russian patent published in 2017 - IPC C07D213/36 C07D401/12 C07D405/12 C07D409/12 C07D491/08 A61K31/4406 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula IB: (IB), where Ar is phenyl or benzyl; R¹ denotes -NR^aR^b, where R^a denotes H, and R^b denotes phenyl; 5-9-member heterocycloalkyl, containing 1 or 2 heteroatoms, independently selected from N or O; 6-10-member aryl; 5-14-member heteroaryl containing 1 or 2 heteroatoms, independently selected from N, S or O; each of said heterocycloalkyl, aryl or heteroaryl is not substituted or is substituted with 1 or 2 substitutes, which can be identical or different, and are independently selected from a group consisting of deuterium, halogen, cyano, C₁-C₆-alkyl, hydroxyl, hydroxyalkyl, hydroxyalkoxy, halogen-C₁-C₆-alkyl, alkoxy, halogen-C₁-C₆-alkoxy, -(CH₂)_q-NR^cR^d, -(CH₂)_q-CONR^cR^d, -S(O)₂-C₁-C₆-alkyl, -S(O)₂NH₂, -C(O)O-C₁-C₆-alkyl, phenyl, 5-member -(CH₂)_qheteroaryl, containing 1 or 2 heteroatoms, independently selected from N, and 5-6-member -(CH₂)_qheterocycloalkyl containing 1 or 2 heteroatoms, independently selected from N or O, wherein each of said heterocycloalkyl or heteroaryl can be substituted with one or more halogen, nitro, halogen-C₁-C₆-alkyl, halogenalkoxy, oxo, cyano, C₁-C₆-alkyl or alkoxy, and R^c and R^d are independently selected from a group, consisting of H, C₁-C₆-alkyl and 3-5-member cycloalkyl; q is equal to 0; for inhibiting NAMPT, their synthesis, use and antidotes.

EFFECT: novel compounds and compositions for inhibiting NAMPT.

26 cl, 3 tbl, 8 ex