DERIVATIVES OF 2-PIPERIDONE AS PROSTAGLANDIN AGONISTS Russian patent published in 2007 - IPC C07D211/76 C07D405/12 A61K31/4015 A61P19/00 A61P19/10 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): wherein m = 1-4; n = 0-4; A means alkyl, aryl, trifluoromethylfuryl, arylalkyl, arylcycloalkyl, cycloalkylalkyl or aryloxyalkyl; E means -CHOH- or -C(O)-; X means -(CH₂)₂- or -CH=CH-; Y means -CH₂-, arylene, -S-; Z means -COOH; each R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹ and R¹⁰ means independently hydrogen atom or alkyl, or its pharmaceutically acceptable salt or solvate, individual isomer or racemic or nonracemic mixture of isomers. Also, invention relates to a pharmaceutical composition and using compounds based on the formula (I) possessing activity as agonists of prostaglandin. Invention provides preparing novel biologically active compounds and pharmaceutical compositions based on thereof possessing activity as agonists of prostaglandin.

EFFECT: valuable biological property of compounds and pharmaceutical compositions.

24 cl, 1 tbl, 7 ex