PROSTAGLANDIN ANALOGS, METHOD FOR THEIR PREPARING AND PHARMACEUTICAL COMPOSITION POSSESSING SELECTIVE AGONISTIC ACTIVITY WITH RESPECT TO EP-RECEPTOR Russian patent published in 2006 - IPC C07D207/27 C07D403/06 C07D405/06 A61K31/4015 A61P19/08 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to analogs of prostaglandin of the formula (I): , wherein A means -CH₂-CH₂- or -CH=CH-; B is absent or means phenyl; Z means -C(O)OR' or tetrazole-5-yl wherein R' means hydrogen atom or (C₁-C₆)-alkyl; m = 1, 2, 3, 4, 5 or 6; R¹ means (C₁-C₆)-alkyl, unsubstituted phenyl or phenyl substituted with at least one substitute chosen from the group comprising trifluoromethyl, halogen atom, -Y-R^a, -Y-OR^a and -Y-C(O)R^a wherein Y means chemical bond or (C₁-C₃)-alkylene group; R^a means (C₁-C₆)-alkyl, unsubstituted phenyl or phenyl substituted with at least one substitute chosen from the group comprising (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, trifluoromethyl and halogen atom under condition that B means phenyl and R³, R⁴, R⁵ and R⁶ do not mean hydrogen atom simultaneously; or R¹ means unsubstituted phenyl or phenyl substituted with at least one substitute chosen from the group comprising trifluoromethyl, -Y-R^a, -Y-OR^a and -Y-C(O)R^a wherein Y means chemical bond or (C₁-C)-alkylene group; R^a means (C₁-C₆)-alkyl, unsubstituted phenyl or phenyl substituted with at least one substitute chosen from the group comprising (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, trifluoromethyl and halogen atom under condition that B is absent and R³, R⁴, R⁵ and R⁶ means hydrogen atom simultaneously; R² means hydrogen atom; each among R³, R⁴, R⁵ and R⁶ means independently of one another hydrogen atom or (C₁-C₆)-alkyl, or its pharmaceutically acceptable salt or individual isomer. Compounds of the formula (1) possess a selective agonistic activity with respect to ER₄-receptors and therefore they can be used in pharmaceutical composition.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.

22 cl, 2 tbl, 12 ex