DERIVATIVES OF 2-PYRROLIDONE AS PROSTANOID AGONISTS AND PHARMACEUTICAL COMPOSITION Russian patent published in 2007 - IPC C07D207/27 C07D207/46 A61K31/4015 A61P9/10 

FIELD: organic chemistry, pharmacy.

SUBSTANCE: invention relates to novel derivatives of 2-pyrrolidone of the formula (I): wherein Q means -CH₂-, -O-; B means -CH₂-, -(CH₂)₂-, -(CH₂)₃-, -(CH₂)₄-, -(CH₂)₅-, -CH=CH-, -CH₂-CH=CH-, -CH=CH-CH₂-, -CH₂-CH=CH-CH₂ under condition that if B means -CH=CH-, -CH=CH-CH₂- then Q means -CH₂-; X means -O-, -S-, -SO- or -SO₂- or a simple bond under condition that if X mean_{a simple bond then Q means oxygen atom; J means -(CR^bR^c)n- wherein n means a whole number from 1 to 4; both R^b and R^c mean hydrogen atom, or both R^b and R^c mean (C1-C4)-alkyl and one of them means hydrogen atom (H), or R^b and R^c in common with carbon atom to which they are bound form (C2-C5)-polymethylene group or -CH2-CH=CH-; A means -CH2-CH2-, -CH=CH- or -C≡C-; Z means -C(O)OR' wherein R' means H, (C1-C6)-alkyl; n means 1, 2, 3 or 4; R¹ means -(CH2)pR⁷ wherein R⁷ means (C1-C)-alkyl, (C3-C8)-cycloalkyl, furanyl substituted with trifluoromethyl, phenyl or phenyl-Y-phenyl wherein Y means oxygen atom (O), a simple chemical bond and phenyl is optionally substituted with 1, 2 or three substitutes chosen independently from group comprising (C1-C6)-alkyl, (C1-C6)-alkoxy-group, halogen atom, halogen-(C1-C6)-alkyl; p means 0, 1, 2, 3, 4, 5; R² means H, (C1-C6)-alkyl; R³, R⁴, R⁵ and R⁶ mean H, or their pharmaceutically acceptable salts or solvates, individual isomers or racemic or nonracemic mixture of isomers. Compounds of the formula (I) elicit competitive affinity in binding EP2, EP3 and EP4 that allows their using as components of pharmaceutical composition.}

EFFECT: valuable medicinal properties of compounds and pharmaceutical compositions.

11 cl, 11 ex