CD73 INHIBITOR, ITS PRODUCTION METHOD AND ITS USE Russian patent published in 2023 - IPC C07H19/16 C07H19/20 C07H19/207 A61K31/70 A61K31/7076 A61K31/7052 A61P35/00 

FIELD: organic chemistry; pharmaceutics.

SUBSTANCE: group of inventions relates to the field of organic chemistry and pharmaceutics; it is aimed at compounds, which are CD73 inhibitors. A compound of the formula (IIb) or the formula (IIc), its stereoisomer, or a pharmaceutically acceptable salt are disclosed, where X₁ is CH in the formula (IIb); Y is O in the formula (IIb); where X₁ is N in the formula (IIc); Y is CH₂ in the formula (IIc); each R₁ is independently selected from hydrogen, halogen, C_1-4 alkyl, where C_1-4 alkyl is optionally substituted with one or more halogens; R₄ is hydrogen or C_1-4 alkyl; R₅ is hydrogen, halogen, or C_1-4 alkyl; R₆ and R₇, each independently, are selected from hydrogen or hydroxy; R₈ and R₉, each independently, are selected from hydrogen or hydroxy; R₁₀, R₁₁, and R₁₂ are hydrogen; q is independently selected from 0, 1, 2, or 3; and m is independently selected from 0, 1, or 2. In addition, a method for the production the above-mentioned compounds, a pharmaceutical composition for the treatment of diseases, which are at least partially mediated by CD73, including a compound of the formula (IIb) or the formula (IIc), and the use of the specified compounds for the production of drugs for diseases, which are at least partially mediated by CD73, are disclosed.

EFFECT: group of inventions provides effective treatment of diseases, which are at least partially mediated by CD73.

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20 cl, 1 tbl, 39 ex