FIELD: organic chemistry, medicine, pharmacy.
SUBSTANCE: invention relates to N-pyrazinylphenylsulfonamides of the general formula (I) 
or their pharmaceutically acceptable salts or solvates wherein each R1, R2 and R3 represents independently hydrogen atom, halogen atom, cyano-group, -CF3, -OCF3, -O-(C1-C6)-alkyl or (C1-C6)-alkyl; R4 represents halogen atom, -CO2R12, (C1-C6)-alkoxy-, (C3-C6)-alkenyloxy- or (C3-C6)-alkynyloxy-group, -O-(C1-C6)-alkyl-X-(C1-C6)-alkyl, -O-(C1-C6)-alkyl-R11, -O-(C2-C6)-alkyl-X-R11 or -O-(C1-C6)-alkyl-R16; each R5 and R6 represents independently hydrogen atom, halogen atom, -CO2R12, -CONR14R15, (C1-C6)-alkyl substituted possibly with hydroxy-group, -NR14R15 or 1-3 fluorine atoms; (C1-C6)-alkyl-R11, -XCH(R11)-(C1-C6)-alkyl or -XCH(R16)-(C1-C6)-alkyl, -NR14R15, -N(R11)R11, X-(CH2)qNR14R15, (CH2)nNR14R15, -NHC(O)-(C1-C6)-alkyl substituted possibly with one or more hydroxy-group, (C3-C6)-alkynyl or (C3-C6)-alkenyl possibly branched and, possibly, substituted with 1-3 groups chosen from hydroxy-, cyano-group, halogen atom and =O. Proposed compounds can be used in treatment of chemokine-mediates diseases, for example, inflammatory diseases, such as asthma. Also, invention describes methods for synthesis of compounds of the formula (I), pharmaceutical composition based on thereof, method for preparing pharmaceutical composition and using compounds in producing a medicinal agent.
EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical composition.
17 cl, 212 ex
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