PYRROLO[2,3-B]PYRIDINE DERIVATIVE AS PROTEIN KINASE INHIBITORS Russian patent published in 2011 - IPC C07D471/04 C07D209/08 C07C49/517 A61K31/435 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention describes a compound of structural formula IIIm: or pharmaceutically acceptable salt thereof, where: R⁸¹ is selected from a group comprising hydrogen, halogen, possibly substituted C₁-₆alkyl, possibly substituted C₂-₆alkenyl, possibly substituted C₂-₆alkynyl, possibly substituted cycloalkyl, possibly substituted heterocycloalkyl, possibly substituted aryl, possibly substituted heteroaryl, -OH, -NH₂, -CN, -NO₂, -C(O)OH, -S(O)₂NH₂, -C(O)NH₂, -C(S)NH₂, -NHC(O)NH₂, -NHC(S)NH₂, -NHS(O)₂NH₂, -OR⁶⁸, -SR⁶⁸, -NR⁶⁹R⁶⁸, -C(O)R⁶⁸, -C(S)R⁶⁸, -C(O)OR⁶⁸, -C(O)NR⁶⁹R⁶⁸, -C(S)NR⁶⁹R⁶⁸, -S(O)₂NR⁶⁹R⁶⁸ _; -NR⁶⁹C(O)R⁶⁸, -NR⁶⁹C(S)R⁶⁸, -NR⁶⁹S(O)₂R⁶⁸, -NR⁶⁹C(O)NH₂, -NR⁶⁹C(O)NR⁶⁹R⁶⁸, -NR⁶⁹C(S)NH₂, -NR⁶⁹C(S)NR⁶⁹R⁶⁸, -NR⁶⁹S(O)₂NH₂, -NR⁶⁹S(O)₂NR⁶⁹R⁶⁸, -S(O)R⁶⁸ and -S(O)₂R⁶⁸, R⁸³ is selected from a group comprising hydrogen, fluro and chloro; R¹¹² is selected from a group comprising possibly substituted C_2-6alkyl, possibly substituted aryl, possibly substituted heteroaryl and -NR⁷⁹ R⁸⁰; R⁶⁸ is selected from a group comprising possibly substituted C_1-6alkyl, possibly substituted C_2-6alkenyl, but provided that when R⁶⁸ is possibly substituted C_2-6alkenyl, then one of its alkene carbons is not bonded with N, S, O, S(O), S(O)₂, C(O) or C(S) from -OR⁶⁸, -SR⁶⁸, -NR⁶⁹R⁶⁸, -C(O)R⁶⁸, -C(S)R⁶⁸, -C(O)OR⁶⁸, -C(O)NR⁶⁹R⁶⁸, -C(S)NR⁶⁹R⁶⁸, -S(O)₂NR⁶⁹R⁶⁸, -NR⁶⁹C(O)R⁶⁸, -NR⁶⁹C(S)R⁶⁸, -NR⁶⁹S(O)₂R⁶⁸, -NR⁶⁹C(O)NH₂, -NR⁶⁹C(O)NR⁶⁹R⁶⁸, -NR⁶⁹C(S)NH₂, -NR⁶⁹C(S)NR⁶⁹R⁶⁸, -NR⁶⁹S(O)₂NH₂, -NR⁶⁹S(O)₂NR⁶⁹R⁶⁸, -S(O)R⁶⁸ or -S(O)₂R⁶⁸, possibly substituted C_2-6alkynyl, but provided that when R⁶⁸ is possibly substituted C_2-6alkynyl, then one of its alkyne carbons is not bonded with N, S, O, S(O), S(O)₂, C(O) or C(S) from -OR⁶⁸, -SR⁶⁸, -NR⁶⁹R⁶⁸, -C(O)R⁶⁸, -C(S)R⁶⁸, -C(O)OR⁶⁸, -C(O)NR⁶⁹R⁶⁸, -C(S)NR⁶⁹R⁶⁸, -S(O)₂NR⁶⁹R⁶⁸, -NR⁶⁹C(O)R⁶⁸, -NR⁶⁹C(S)R⁶⁸, -NR⁶⁹S(O)₂R⁶⁸, -NR⁶⁹C(O)NH₂, -NR⁶⁹C(O)NR⁶⁹R⁶⁸, -NR⁶⁹C(S)NH₂, -NR⁶⁹C(S)NR⁶⁹R⁶⁸, -NR⁶⁹S(O)₂NH₂, -NR⁶⁹S(O)₂NR⁶⁹R⁶⁸, -S(O)R⁶⁸ or -S(O)₂R⁶⁸, possibly substituted cycloalkyl, possibly substituted heterocycloalkyl, possibly substituted aryl and possibly substituted heteroaryl; R⁶⁹ is selected from a group comprising hydrogen and possibly substituted C_1-6alkyl; and R⁷⁹ and R⁸⁰ independently denote hydrogen or possibly substituted C_1-6alkyl or R⁷⁹ and R⁸⁰ together with the nitrogen atom to which they are bonded form a possibly substituted 5-7-member heterocycloalkyl. Described also is a composition and a set for modulating protein kinase based on said compounds and use of said compounds in preparing a medicinal agent.

EFFECT: novel compounds which are active towards protein kinase are obtained and described.

71 cl, 59 ex