PYRIDINE DERIVATIVES FOR TREATING METABOLIC DISORDERS ASSOCIATED WITH INSULIN RESISTANCE OR HYPERGLYCAEMIA Russian patent published in 2012 - IPC C07D213/75 C07D213/76 C07D401/12 C07D417/12 A61K31/4439 A61K31/496 A61P3/10 A61P1/16 A61P15/08 A61P3/04 A61P3/06 A61P31/00 A61P35/00 A61P9/10 A61P9/12 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of general formula (I) and pharmaceutically acceptable salts thereof, where Ar denotes a phenyl group substituted with piperazine or benzo[d]thiazole, with a phenyl part bonded to B, where the piperazine or benzo[d]thiazole can be unsubstituted or substituted with substitutes selected from alkyl or acetyl; B denotes -O-; R¹ denotes hydrogen; R² denotes S(O)₂R⁴ or C(O)(CH₂)_n-C(O)OR⁵; R³ denotes halogen; R⁴ denotes an aryl which can be unsubstituted or substituted with substitutes selected from a group comprising halogen, alkyl, fluoroalkyl, alkoxy and trifluoromethoxy; R⁵ denotes hydrogen; n is a whole number from 1 to 3. The invention also relates to a method of producing said compounds and a pharmaceutical composition for treating metabolic disorders associated with insulin resistance or hyperglycaemia, based on said compounds.

EFFECT: novel compounds are obtained, which can be used in medicine to treat type 2 diabetes, obesity, glucose intolerance, dyslipidaemia, hyperinsulinaemia, atherosclerotic disease, polycystic ovary syndrome, coronary artery disease, hypertension or non-alcoholic fatty liver disease.

28 cl, 3 dwg, 4 tbl, 22 ex