COMBINATIONS CONTAINING TRANSDUCTION SIGNAL INHIBITOR AND EPOTILONE DERIVATIVE Russian patent published in 2007 - IPC A61K31/505 A61K31/426 A61P35/00 

FIELD: medicine, pharmacy.

SUBSTANCE: invention describes a combination containing: (a) inhibitor of signal transduction chosen from inhibitor of tyrosinase receptor PDGF (thrombocyte growth factor) and active substance that decreases activity of epidermal growth factor (EGF), and (b) derivative of epotilone of the formula (I) given in the invention description wherein A represents oxygen atom (O) or nt_n wherein r_n means hydrogen atom or (lower)-alkyl; R means hydrogen atom or (lower)-alkyl; Z means O or a bond, and optionally at least one pharmaceutically acceptable carrier. Also, invention relates to a combination designated for simultaneous, separated or successive using, in particular, for the development retention or treatment of proliferative disease, to a pharmaceutical composition comprising such combination, using such combination in preparing a drug designated for the development retention or treatment of proliferative diseases, package or product containing such combination used as a combined medicinal agent, and to a method for treatment of warm-blooded animal. The combination exceeds effect of each components of its.

EFFECT: enhanced and valuable medicinal properties of combination and pharmaceutical composition.

14 cl, 2 ex