FIELD: chemical-pharmaceutical industry.
SUBSTANCE: invention refers to pharmaceutical combination including (a) alkylating agent and (b) epothilone derivative of formula 
where A represents O or NRN, where RN represents hydrogen or lower alkyl, R represents hydrogen or lower alkyl and Z represents O or bonding.
EFFECT: it can be useful for proliferative disease treatment, especially tumour disease, and proliferative action is greater in comparison with maximum action which can be reached with each component separately.
8 cl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| COMBINATIONS INCLUDING EPOTHILONES, AND THEIR PHARMACEUTICAL APPLICATION | 2002 |
|
RU2375058C2 |
| COMBINATIONS INCLUDING EPOTHILONES AND THEIR PHARMACEUTICAL APPLICATION | 2003 |
|
RU2379032C9 |
| COMBINATIONS CONTAINING EPOTHILONES AND PROTEIN KINASE INHIBITORS AND PHARMACEUTICAL APPLICATION THEREOF | 2005 |
|
RU2423980C2 |
| COMBINATIONS CONTAINING ANTIDIARRHEAL AGENT AND EPOTHYLON OR EPOTHYLON DERIVATIVES | 2002 |
|
RU2330661C2 |
| TREATMENT OF PROLIFERATIVE DISEASES WITH EPOTHILONE DERIVATIVES AND RADIATION | 2004 |
|
RU2381799C2 |
| COMBINATIONS CONTAINING TRANSDUCTION SIGNAL INHIBITOR AND EPOTILONE DERIVATIVE | 2002 |
|
RU2313345C2 |
| COMBINATIONS CONTAINING EPOTHILONES AND ANTIMETABOLITES | 2003 |
|
RU2346686C2 |
| COMPOSITIONS CONTAINING SELECTIVE INHIBITOR OF CYCLOOXYGENASE-2 | 2002 |
|
RU2333754C2 |
| EPOTHILONE DERIVATIVE FOR TREATMENT OF HEPATOME AND OTHER CANCER DISEASES | 2003 |
|
RU2358730C2 |
| COMPOSITIONS CONTAINING EPOTHILONES, AND APPLICATION THEREOF FOR CARCINOID SYNDROME TREATMENT | 2002 |
|
RU2341261C2 |
