FIELD: medicine.
SUBSTANCE: present invention concerns medical products, particularly pharmaceutical combination for development inhibition or treatment of proliferative disease which contains in therapeutically effective amounts (a) compound PTK787 and (b) epothilone derivative of formula 
, where A means O or NRN, where RN means hydrogen or lower alkyl, R means hydrogen or lower alkyl, and Z means oxygen or chain, for simultaneous, separate or consecutive application. Besides the invention concerns a pharmaceutical composition, application and commercial package thereof.
EFFECT: specified combination of active components ensures synergetic effect in treatment of proliferative diseases.
7 cl, 6 ex
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