METHOD FOR SYNTHESIS OF CHIRAL N-ARYLPIPERAZINES Russian patent published in 2008 - IPC C07D319/18 C07D405/12 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a novel method for synthesis of compound of the formula (VII) , formula (VIII) and formula (IX) that effect on 5-HT-receptors of the central nervous system. In compound of the formula (VII) R represents (C₁-C₃)-alkyl; Y represents fragment chosen from group comprising (C₁-C₆)-alkoxy-group, (C₁-C₆)-alkyl; Ar represents 2,3-dihydrobenzodioxin-5-yl. In compound of the formula (VIII) R represents (C₁-C₃)-alkyl; Ar represents 2,3-dihydrobenzodioxin-5-yl, and * indicated the chiral center. In compound of the formula (IX) R and Ar are given above; Aryl represents (C₆-C₁₂)-aromatic group substituted optionally and comprising up to three substitutes chosen independently from group comprising halogen atoms, alkyl, alkoxy-group, alkoxycarbonyl, nitro-, amino-, alkylamino-, dialkylamino-group, halogenalkyl, dihalogenalkyl, trihalogenalkyl, nitrile and amido-substitutes wherein each comprises six carbon atoms, not above.

EFFECT: improved method of synthesis, valuable medicinal properties of compounds.

11 cl, 9 ex