NOVEL COMPOUNDS POSSESSING ANTI-INFLAMMATORY ACTIVITY AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEREOF Russian patent published in 2006 - IPC C07D307/38 C07D307/58 A61K31/341 A61K31/40 A61P29/00 

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to novel compounds of the formula (I): wherein R¹ represents alkyl; R² represents halogen atom, formyl, substituted or unsubstituted alkyl, hydroxyl, (C₁-C₆)-alkoxy-group, halogenalkyl; or R and R² in common with atom to which they are bound form unsubstituted 5-7-membered structure of the formula: -CH₂-(CH₂)_nS- wherein n = 1 or 2; R³ represents hydrogen atom, halogen atom or alkyl; R⁴ represents alkoxy-group or unsubstituted aryl or aryl substituted with halogen atom, (C₁-C₆)-alkyl, halogenated (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-group, (C₁-C₆)-alkylsulfonyl; R⁵ represents hydrogen atom, hydroxyl, alkyl, alkenyl or alkoxy-group; R⁶ represents hydrogen atom or alkyl; or R⁵ and R⁶ represent in common =O; X represents oxygen atom or -NR⁸ wherein R⁸ represents aryl substituted with halogen atom; m means a whole number in the range from 0 to 2, and its pharmaceutically acceptable salts. Also, invention relates to pharmaceutical compositions based on these compounds, method for treatment of diseases mediated by cyclooxygenase and to a method for inhibition of cyclooxygenase activity in cells. Invention provides preparing novel compounds possessing valuable biological effect.

EFFECT: valuable medicinal and biochemical properties of compounds and pharmaceutical compositions.

11 cl, 98 ex