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(19)

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2 679 914

(13)

(51)

IPC

C07D471/04(2006-01-01)

C07D519/00(2006-01-01)

A61K31/437(2006-01-01)

A61P1/00(2006-01-01)

A61P19/02(2006-01-01)

(21) (22)

Application

2016126974, 2014-12-08

(24)

Start date

2014-12-08

(22)

Actual filing date

2014-12-08

(45)

Published

2019-02-14

(72)

Inventor

Aleksander Rikki PiterBrejs Garet NilBraun Dzhulien AlisterKalmiano Mark DanielChovatiya Praful TulshiDelini MikhaelGallimor Ellen OliviyaKher Yag PaulDzhekson Viktoriya ElizabetKroplin BorisMak-Koss MalkolmKuinsi Dzhoanna RejchelSabnis Jogesh AnilSvinnen Dominik Lui LeonChzhu ChzhaoninKhajnelt UveVener Folkmar

(73)

Holder

Yusb Bajofarma Sprl

FUSED TRICYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY Russian patent published in 2019 - IPC C07D471/04 C07D519/00 A61K31/437 A61P1/00 A61P19/02

Abstract RU 2679914 C9

FIELD: chemistry.

SUBSTANCE: present invention relates to a novel condensed imidazole derivative of formula (IIA) or to its pharmaceutically acceptable salt, to a pharmaceutical composition containing said compounds, to the use of said compounds and to a method of treating and / or preventing Crohn's disease or rheumatoid arthritis.

(IIA). In formula (IIA), the values of R¹, R², R^5a, R^5b, Y, Z are as defined in the claims.

EFFECT: treatment and / or prevention of Crohn's disease or rheumatoid arthritis.

16 cl, 271 ex

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RU 2 679 914 C9

Authors

Aleksander Rikki Piter

Brejs Garet Nil

Braun Dzhulien Alister

Kalmiano Mark Daniel

Chovatiya Praful Tulshi

Delini Mikhael

Gallimor Ellen Oliviya

Kher Yag Paul

Dzhekson Viktoriya Elizabet

Kroplin Boris

Mak-Koss Malkolm

Kuinsi Dzhoanna Rejchel

Sabnis Jogesh Anil

Svinnen Dominik Lui Leon

Chzhu Chzhaonin

Khajnelt Uve

Vener Folkmar

Dates

2019-02-14—Published

2014-12-08—Filed