NUCLEOPHILIC FLUORINATION IN SOLID PHASE Russian patent published in 2008 - IPC C07H5/02 C07H5/00 C07F13/00 A61K51/04 C07H19/00 C07H11/00 C07B59/00 C07C17/20 C07C253/30 C07C255/42 C07C311/03 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to an improved solid-phase method for synthesis of radioisotope indicators, in particular, for synthesis of compounds labeled with ¹⁸F that can be used as radioactive indicators for positron- emission tomography (PET). In particular, invention relates to a method for synthesis of indicator labeled with ¹⁸F that involves treatment of a precursor fixed on resin if the formula (I): SOLID CARRIER-LINKER-X-INDICATOR wherein X means a group promoting to nucleophilic substitution by a definite center of a fixed INDICATOR with ¹⁸F^- ion for preparing a labeled indicator of the formula (II): ¹⁸F-INDICATOR; to compound of the formula (Ib):

and compound of the formula (Ih): ;

to radiopharmaceutical set of reagents for preparing indicator labeled with ¹⁸F for using in PET; to a cartridge for radiopharmaceutical set of reagents for preparing indicator labeled with ¹⁸F for using in positron-emission tomography.

EFFECT: improved method of synthesis.

13 cl, 1 sch, 3 ex