NOVEL PRECURSORS OF GLUTAMATE DERIVATIVES Russian patent published in 2016 - IPC C07B59/00 C07C227/16 C07C227/18 C07C229/24 C07C309/73 C07C309/74 C07D215/36 A61K49/00 

Abstract RU 2600981 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to a compound of formula I. Formula I , in which R1 is a triphenylmethyl (trityl), A is selected from: a) a monocyclic C6-10-aryl, b) a bicyclic C6-10-aryl, c) C12-20-biaryl, d) monocyclic heteroaryl and e) a bicyclic heteroaryl, where heteroaryl is an aromatic, mono- or bicyclic divalent radical, having 5 to 10 ring atoms and an N heteroatom, optionally, A has one or more substitutes selected from a group comprising: a) halogen, b) nitro, c) alkyl, d) trifluoromethyl and e) Z, where Z is , R1 is a triphenylmethyl radical (trityl), # indicates position of bond with A, and separate isomers, tautomers, diastereomers, enantiomers, stereoisomers, mixtures thereof and salts thereof. Invention also discloses a method of producing compounds of formula I, fluorine-labelled glutamate derivatives, compositions.

EFFECT: invention enables to provide stable, optically pure, solid and sufficiently reactive precursors for producing fluorine-labelled glutamate derivatives.

17 cl, 3 tbl, 14 ex

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RU 2 600 981 C2

Authors

Khulch Kristina

Kharre Mikhael

Novak Filip

Berndt Matias

Fribe Mattias

Shmitt-Villikh Kheribert

Yun Chi Dae

Li Ben Se

Park San Don

Dates

2016-10-27Published

2012-04-30Filed