FIELD: medicine, in particular treatment of pathological diseases mediated by activated macrophages.
SUBSTANCE: Disclosed is pharmaceutical composition containing conjugate or complex of general formula Ab-X and uses thereof in production of pharmaceutical composition, wherein Ab group contains ligand capable of binding to vitamin receptor, and X group contains immunogen, cytotoxin, or compound capable of macrophage function reducing. Pathological conditions mediated by activated macrophages are selected from group including Crone disease, inflammations, infections, organ transplant rejection, osteomyelitis, etc.
EFFECT: improved method for treatment and diagnosis of macrophage mediated diseases.
26 cl, 15 dwg, 19 ex
| Title |
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