POLY-LIGAND MEDICINAL CONJUGATES AND USE THEREOF Russian patent published in 2020 - IPC A61K47/50 A61P35/00 

FIELD: medicine.

SUBSTANCE: group of inventions concerns a conjugated compound or its pharmaceutically acceptable salt for delivering a payload to a patient, containing at least one payload and two or more types of molecules interacting with cells, wherein the payload is conjugated with at least one of the molecules interacting with the cells, wherein the two or more types of molecules interacting with the cells include a) a first ligand, capable of specifically binding to a first cell surface receptor, and a second ligand capable of specifically binding to a second cell surface receptor, wherein the first and second cell surface receptors differ from each other; or b) a first ligand capable of specifically binding to a first cell surface receptor, and an endocytosis molecule, able to mediate endocytosis. Group of inventions also relates to a pharmaceutical composition for delivering a payload to a patient comprising said compound; method of treating a disease in a patient, comprising administering to a patient a therapeutically effective amount of said compound.

EFFECT: group of inventions provides effective drug delivery into patient's cells.

38 cl, 3 ex, 4 dwg, 17 tbl