FIELD: medicine; pharmaceutics.
SUBSTANCE: invention relates to the field of medicine and pharmaceutics, namely to a combination of ectophosphatase with methotrexate (MTX) for the use in the treatment of a mammalian suffering from arthritis, wherein this ectophosphatase is tissue-specific ectophosphatase and is selected from intestinal alkaline phosphatase (IAP) or placental alkaline phosphatase (PALP), and the specified treatment is the treatment of chronic arthritis.
EFFECT: invention provides an increase in the effectiveness of the treatment of chronic arthritis while reducing side effects.
9 cl, 12 dwg, 1 tbl, 1 ex
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