FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to medicine, and may be used for preparing a composition for diagnosing/monitoring of a patient suffering from a disease state mediated by activated macrophages. What is used is a composition comprising a conjugate or a complex of general formula Ab-X wherein the group Ab contains a ligand binding folate receptor which binds to activated macrophages. The group X contains an imaging agent wherein the ligand binding folate receptor is conjugated to the imaging agent by γ-carboxyl group of glutamic acid, of the ligand binding folate receptor.
EFFECT: enabled diagnosing or monitoring of the following diseases: rheumatoid arthritis, ulcerative colitis, Crohn's disease, skin infections, osteomyelitis, atherosclerosis, organ transplant rejection, pulmonary fibrosis, sarcoidosis, scleroderma, and chronic inflammation, due to the imaging agents within locations of the populations of activated macrophages and inside of them.
17 cl, 15 dwg, 19 ex
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