FIELD: medicine, pharmacy.
SUBSTANCE: invention describes immunosuppressive pharmaceutical compositions containing the following components: (a) ISATx247 taken in the pharmaceutically effective amount; (b) vitamin E TPGC (d-α-tocopheryl-polyethylene glycol(1000)-succinate); (c) MCT oil; (d) emulsifier chosen from group consisting of Tween-40 and Tween-80, and (e) ethanol. This pharmaceutical composition forms a clear microemulsion after contact with aqueous medium. Compositions provide high biological availability of drug and/or decrease one or more adverse effects associated with administration of ciclosporin. Also, invention discloses methods for using and preparing these compositions.
EFFECT: valuable medicinal and pharmaceutical properties of compositions.
39 cl, 7 tbl, 5 dwg, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PHARMACEUTICAL COMPOSITIONS | 2011 |
|
RU2639482C2 |
| CYCLOSPORIN-CONTAINING AND PRACTICALLY OIL-FREE COMPOSITIONS | 2000 |
|
RU2249461C2 |
| MICROEMULSION PRECONCENTRATE | 2002 |
|
RU2278657C2 |
| PHARMACEUTICAL COMPOSITION, PRODUCT OF TRANSESTERIFICATION OF CORN OIL WITH GLYCEROL AND METHOD OF ITS PREPARING | 1992 |
|
RU2143919C1 |
| CYCLOSPORINE ANALOGUES MIXTURE AND ITS APPLICATION AS IMMUNOMODULATORY AGENT | 2002 |
|
RU2337106C2 |
| MICROEMULSION PRECONCENTRATE | 1995 |
|
RU2181054C2 |
| PHARMACEUTICAL COMPOSITION, USING CARBOXYLIC ACID FOR STABILIZING MACROLIDE IN THIS COMPOSITION AND METHOD FOR STABILIZING MACROLIDE | 1995 |
|
RU2292887C2 |
| PHARMACEUTICAL COMPOSITION CONTAINING CYCLOSPORIN DERIVATIVE AND A METHOD OF ITS PREPARING | 1993 |
|
RU2126263C1 |
| PRELIMINARY PREPARED EMULSION CONCENTRATES CONTAINING CYCLOSPORINE OR MACROLIDE | 1999 |
|
RU2235554C2 |
| SELF-EMULSIFYING COMPOSITION FOR SCARCELY WATER-SOLUBLE MEDICAMENT | 1999 |
|
RU2257917C2 |
