FIELD: pharmaceutical chemistry.
SUBSTANCE: pharmaceutical composition comprises efficient amount of lipophilic medicament in combination with pharmaceutical carrier. The latter consists of propylene glycol esters of C6-C18-fatty acid with 90 wt % monoester and nonionic surfactant, whose hydrophilic/lipophilic balance exceeds 10 and is suitable to solubilize lipophilic medicament. Above-mentioned surfactant is present in amount high enough to form microemulsion with ester and medicament when in contact with aqueous medium. Preferably medicament is cyclosporine.
EFFECT: increased stability of composition to provide desired pharmacokinetics and biological accessibility of lipophilic drugs essentially non soluble in water.
34 cl, 10 ex
