METHOD FOR PREDICTING THE PROGRESSING FLOW OF CHRONIC HEPATITIS C (DEVELOPMENT OF CIRRHOSIS) DUE TO ANALYZING THE COMBINATION OF POLYMORPHISMS OF CYTOKINS GENES Russian patent published in 2008 - IPC C12Q1/68 C12N15/24 

FIELD: molecular biology, medicinal genetics.

SUBSTANCE: the present innovation could be applied in clinical practice for predicting the flow of chronic hepatitis C (CHC). It has been suggested a predictive model that enables to evaluate the risk for the development of hepatic fibrosis (development of cirrhosis) in case of CHC. The present model is based upon the sum of the results of DNA assay in patients for the presence of polymorphisms of cytokins genes(-511)C/T IL-lb, (-174) G/C IL-6 gene and (+915) G/C TGF-bl gene. Moreover, it has been established that genotypes (-511) TT IL-lb gene, (-174) CC IL-6 gene and (+915) GC TGF-bl gene are characterized with pronounced "profibrotic" action; genotypes (-511) CT IL-lb gene and (-174) GC IL-6 gene - with moderate "profibrotic" action; genotypes (-511) CC IL-lb gene, (-174) GG IL-6 gene - with protective action concerning the development of cirrhosis, and genotype (+915) GC TGF-bl gene is being neutral. The present innovation enables to detect the high-risk group of cirrhosis development in CHC-patients that needs intensive antiviral and in future - in antifibrotic therapy.

EFFECT: higher accuracy of prediction.

5 dwg, 6 ex, 11 tbl