METHOD FOR PREDICTION OF RISK OF ENDOMETRIOSIS Russian patent published in 2015 - IPC G01N33/48 G01N33/53 

FIELD: medicine.

SUBSTANCE: DNA is recovered from peripheral venous blood; combinations of genetic versions of polymorphous markers of interleukin 6 (-174 G/C IL-6), interleukin 1B (-511 C/T IL-1B), interleukin 10 (-592 C/A IL-10) cytokine genes, stromal cell factor (-801 G/A SDF1) chemokine genes, macrophage inflammatory protein -1β (+1931 A/T MIP 1β), T-cell normal expression and secretion activity regulator (-403 G/A RANTES), interferon-inducible T-cell chemoattractant (A/G I-TAC) are typed and analysed. A high risk of isolated endometriosis is predicted if observing combinations of -174 C IL-6, -801 A SDF1, +1931 A MIP1β, -592 C IL-10 alleles, -801 A SDF1, -403 G RANTES, +1931 A MIP1β, -592 C IL-10 alleles, -801 A SDF1, -403 G RANTES, -511 C IL-1B, -592 C IL-10 alleles, -801 A SDF1, +1931 A MIP1β, -592 C IL-10 alleles, -174 C IL-6, -801 A SDF1, -403 G RANTES, -592 C IL-10 alleles, -801 A SDF1, A I-TAC, -511 CC IL-1B alleles.

EFFECT: simple non-invasive diagnostic technique for endometriosis that increases a risk of recurrence upon the completion of any therapeutic method, both conservative, and surgical.

5 dwg, 1 tbl, 1 ex