METHOD FOR PREPARING 2-(AZOL-1-YL)ETHANEAMINES Russian patent published in 2008 - IPC C07D233/61 C07D235/04 C07D249/08 

FIELD: organic chemistry, chemical technology.

SUBSTANCE: invention relates to a method for synthesis of 2-(azol-1-yl)ethaneamines that are used as the parent compounds in preparing biologically active compounds of medicinal and agriculture designation. Method for synthesis of 2-(azol-1-yl)ethaneamines of the general formula (I): wherein R¹ means hydrogen atom or alkyl group comprising from 1 to 6 carbon atoms; each Z and X means independently -CH or nitrogen atom (N); or Z and X mean in common group -C-CH=CH-CH=CH-C that forms a system anellated with azole cycle involves the alkylation reaction of azole compounds wherein R¹, Z and Y have the same values as in the formula (I) with oxazolines of the formula (II): wherein R² means alkyl group comprising from 1 to 6 carbon atoms, phenyl, halogenphenyl group in the presence of Lewis acid or protonic acid to yield N-[2-(azol-1-yl)ethyl]alkaneamides of the formula (III): wherein R¹, R², Z and X have above given values followed by their hydrolysis in the presence of acids or bases in polar solvent medium at temperature 60-120°C.

EFFECT: improved method of synthesis.

5 cl, 17 ex