FIELD: chemistry.
SUBSTANCE: described are novel substituted O-[ω-(azol-1-yl)alkyl]-N-phenylcarbamates of general formula I:
,
where Z and Y=CH, N or together form an annulated ring with a C-CH=CH-CH=CH-C chain; or Y=CH, Z denotes a nitrogen atom, m=1-3; R=Hal, alkyl, alkoxycarbonyl, sulphamoyl, nitro etc, n=0-2, and pharmaceutically acceptable salts thereof, which are obtained by acylating the corresponding ω-(azol-1-yl)-1-alkanol with phenyl isocyanates in polar aprotic solvents at temperature of 20-100°C, preferably in the presence of organic bases as catalysts.
EFFECT: antiaggregatory activity of certain O-[ω-(azol-1-yl)alkyl]-N-phenylcarbamates of general formula I, eg O-[2-(1H-imidazol-1-yl)ethyl]-N-(3-trifluoromethylphenyl)carbamate hydrochloride is higher than that of dazoxybene.
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