FIELD: organic chemistry, chemistry of heterocyclic compounds.
SUBSTANCE: invention relates to heterocyclic compounds possessing the potential biological activity, in particular, to a method for synthesis of 2-methyl-5-substituted 1,3,4-oxadiazoles. Invention describes a method for synthesis of 2-methyl-5R-substituted 1,3,4-oxadizoles wherein R means aryl, hetaryl or alkyl by the cyclization reaction of tributylstannyl derivatives of tetrazole in the presence of aliphatic acid anhydrides by the following scheme: 
. Method provides preparing 2-methyl-1,3,4-oxadiazoles substituted with bulky substitutes at position 5 by simplified technology.
EFFECT: improved and simplified method of synthesis.
8 ex
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