FIELD: chemistry.
SUBSTANCE: invention relates to the method of production of analogues of natural alkaloids of harman series (eleagnine) having potential biological activity, namely, to the method of 1-substituted -4phenyl-2,3,4,9-terahydro-1H-beta-carboline of general formula 
where one of R1 and R2 denotes hydrogen atom, and the other represents alkyl with 1 or 2 hydrogen atoms or aryl, hetaryl, or R1 and R2 together with carbon atom to which they are banded derive optionally substituted indol-3-on. The method is cyclisation of aldehydes by substituted tryptamine with acids, at the same time beta-phenyltryptamine is used as substituted tryptamine, aliphatic or aromatic aldehydes or optionally substituted isatins are used as aldehydes, mineral salts or Lewis catalysts are used as acids.
EFFECT: production of analogues of natural alkaloids of harman series (eleagnine) having potential biological activity.
1 cl, 4 tbl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| ESTROGEN RECEPTOR MODULATORS | 2017 |
|
RU2738646C2 |
| BETA-CARBOLINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS BASED ON THEREOF AND METHODS FOR BINDING, ATTAINMENT OF AGONISTIC/ANTAGONISTIC EFFECT | 1999 |
|
RU2233841C2 |
| METHOD OF PREPARING 3-INDOLYLPHENYLMETHYL-2-SUBSTITUTED CYCLIC ALPHA-KETONES | 2004 |
|
RU2302409C2 |
| DERIVATIVES OF SUBSTITUTED PYRROLOPYRIDINONE USEFUL AS PHOSPHODIESTERASE INHIBITORS | 2001 |
|
RU2267490C2 |
| METHOD FOR PREPARING 2-METHYL-5-SUBSTITUTED 1,3,4-OXADIAZOLES | 2004 |
|
RU2317986C2 |
| HETEROARYL COMPOUNDS, COMPOSITIONS CONTAINING THEM AND METHODS OF TREATING WITH USE OF SUCH COMPOUNDS | 2007 |
|
RU2478635C2 |
| SPIRO(5,5)UNDECANE DERIVATIVES | 2009 |
|
RU2515895C2 |
| DERIVATIVES OF BETA-CARBOLINE POSSESSING EFFECT OF PHOSPHODIESTERASE INHIBITORS, PHARMACEUTICAL COMPOSITION (VARIANTS), METHOD FOR ITS PREPARING, METHOD FOR INHIBITION OF PHOSPHODIESTERASE EFFECT (VARIANTS) AND METHOD FOR INCREASING CGMP CONCENTRATION | 2001 |
|
RU2271358C2 |
| β-CARBOLINE DERIVATIVES, POSSESSING ANTI-TUBERCULOSIS ACTIVITY, THEIR APPLICATION FOR MEDICATION MANUFACTURING, METHOD OF THEIR SYNTHESIS, AS WELL AS NOVEL METHODS OF TREATMENT WITH THEIR APPLICATION | 2010 |
|
RU2419431C1 |
| N,N-DISUBSTITUTED NICOTINAMIDE-(Z)-O-METHYLOXIMES CHARACTERIZED BY FUNGICIDAL ACTIVITY | 2010 |
|
RU2442784C1 |
