FIELD: organic synthesis.
SUBSTANCE: invention provides a method of preparing 3-indolylphenylmethyl-2-substituted cyclic alpha-ketones having general formula: 
, in which R represents 1 or 2 carbon atoms with annelated benzene ring or substituted methylidene group, in particular 2-methylpropylidene or 2-phenylmethylidene group, and consists in that α-phenyl-norgramine is brought into reaction with cyclic ketone of general formula: 
, wherein R is defined above, in boiling isopropyl alcohol in presence of sodium acetate, pyridine, triethylamine, alkali, or chiral amine as base.
EFFECT: expanded synthetic possibilities in a series of indolyl derivatives.
3 tbl, 6 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PREPARING 2-METHYL-5-SUBSTITUTED 1,3,4-OXADIAZOLES | 2004 |
|
RU2317986C2 |
| METHOD OF PRODUCTION OF 1- AND 1,1-DISUBSTITUTED-4-PHENYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE | 2004 |
|
RU2332418C2 |
| N,N-DISUBSTITUTED NICOTINAMIDE-(Z)-O-METHYLOXIMES CHARACTERIZED BY FUNGICIDAL ACTIVITY | 2010 |
|
RU2442784C1 |
| SUBSTITUTED 1-(PYRIDINYL-2)-2-AZOLYLETHANOLES, METHOD FOR THEIR PREPARING AND FUNGICIDE COMPOSITION BASED ON THEREOF | 2004 |
|
RU2301227C2 |
| SUBSTITUTED 2-THIOCARBAMOYL-3-PHENYL-3,3a,4,5,6,7-HEXAHYDRO-2N-INDAZOLES, METHOD OF PRODUCING SAID COMPOUNDS (VERSIONS) AND FUNGICIDE COMPOSITION BASED ON SAID COMPOUNDS | 2008 |
|
RU2374233C1 |
| 2-ALKYLTHIO-5-(1H-1,2,4,-TRIAZOLE-1-ILMETHYL)-1,3,4-THIADIAZOLES, METHOD FOR PRODUCTION THEREOF AND FUNGICIDAL COMPOSITIONS BASED THEREON | 2020 |
|
RU2757808C1 |
| SUBSTITUTED METHYL-N-AMIDOOXAMOYL-N-PHENYL-D,L-ALANINATES AND A METHOD FOR PREPARATION THEREOF | 2003 |
|
RU2247716C2 |
| 1-(PYRIDINYL-2)-2-AZOLYL-1-(FLUOROPHENYL)ETHANOLS AND THEIR USING AS FUNGICIDES | 2004 |
|
RU2267483C2 |
| METHOD FOR PREPARING 3,4-DIARYL(HETARYL)MALEIMIDES | 2005 |
|
RU2278855C1 |
| N4-SUBSTITUTED 3-ALKYLSULPHANYL-5-(1,2,4-TRIAZOLE-1-YLMETHYL)-1,2,4-TRIAZOLES, METHOD FOR PRODUCTION THEREOF, FUNGICIDE AND GROWTH REGULATORY COMPOSITION ON THEIR BASIS | 2017 |
|
RU2668212C1 |
