FIELD: organic synthesis.
SUBSTANCE: invention provides a method of preparing 3-indolylphenylmethyl-2-substituted cyclic alpha-ketones having general formula: 
, in which R represents 1 or 2 carbon atoms with annelated benzene ring or substituted methylidene group, in particular 2-methylpropylidene or 2-phenylmethylidene group, and consists in that α-phenyl-norgramine is brought into reaction with cyclic ketone of general formula: 
, wherein R is defined above, in boiling isopropyl alcohol in presence of sodium acetate, pyridine, triethylamine, alkali, or chiral amine as base.
EFFECT: expanded synthetic possibilities in a series of indolyl derivatives.
3 tbl, 6 ex
| Title |
Year |
Author |
Number |
| METHOD FOR PREPARING 2-METHYL-5-SUBSTITUTED 1,3,4-OXADIAZOLES |
2004 |
- Semenov Boris Borisovich
- Smushkevich Jurij Isaevich
|
RU2317986C2 |
| METHOD OF PRODUCTION OF 1- AND 1,1-DISUBSTITUTED-4-PHENYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE |
2004 |
- Semenov Boris Borisovich
- Novikov Kirill Aleksandrovich
- Kachala Vadim Vadimovich
|
RU2332418C2 |
| N,N-DISUBSTITUTED NICOTINAMIDE-(Z)-O-METHYLOXIMES CHARACTERIZED BY FUNGICIDAL ACTIVITY |
2010 |
- Martsynkevich Andrej Mikhajlovich
- Zakharychev Vladimir Vladimirovich
- Sharanina Natal'Ja Ivanovna
|
RU2442784C1 |
| SUBSTITUTED 1-(PYRIDINYL-2)-2-AZOLYLETHANOLES, METHOD FOR THEIR PREPARING AND FUNGICIDE COMPOSITION BASED ON THEREOF |
2004 |
- Zakharychev Vladimir Vladimirovich
- Kuzenkov Aleksandr Vladimirovich
|
RU2301227C2 |
| SUBSTITUTED 2-THIOCARBAMOYL-3-PHENYL-3,3a,4,5,6,7-HEXAHYDRO-2N-INDAZOLES, METHOD OF PRODUCING SAID COMPOUNDS (VERSIONS) AND FUNGICIDE COMPOSITION BASED ON SAID COMPOUNDS |
2008 |
- Gar Mikhail Mikhajlovich
- Popkov Sergej Vladimirovich
- Arkhipova Ol'Ga Nikolaevna
|
RU2374233C1 |
| 2-ALKYLTHIO-5-(1H-1,2,4,-TRIAZOLE-1-ILMETHYL)-1,3,4-THIADIAZOLES, METHOD FOR PRODUCTION THEREOF AND FUNGICIDAL COMPOSITIONS BASED THEREON |
2020 |
- Tsaplin Grigorij Valerevich
- Popkov Sergej Vladimirovich
- Orlova Anastasiya Sergeevna
- Alekseenko Anna Leonidovna
|
RU2757808C1 |
| SUBSTITUTED METHYL-N-AMIDOOXAMOYL-N-PHENYL-D,L-ALANINATES AND A METHOD FOR PREPARATION THEREOF |
2003 |
- Filippova T.E.
- Chzhan Ts.Sh.
- Kovalenko L.V.
- Zakharychev V.V.
|
RU2247716C2 |
| 1-(PYRIDINYL-2)-2-AZOLYL-1-(FLUOROPHENYL)ETHANOLS AND THEIR USING AS FUNGICIDES |
2004 |
- Zakharychev Vladimir Vladimirovich
- Kuzenkov Aleksandr Vladimirovich
- Popkov Sergej Vladimirovich
|
RU2267483C2 |
| METHOD FOR PREPARING 3,4-DIARYL(HETARYL)MALEIMIDES |
2005 |
- Krajushkin Mikhail Mikhajlovich
- Stojanovich Feliks Markelovich
- Shorunov Sergej Valer'Evich
- Irie Masakhiro
|
RU2278855C1 |
| TAXANE DERIVATIVES, METHOD OF THEIR SYNTHESIS, PHARMACEUTICAL COMPOSITION AND METHOD OF TREATMENT |
1994 |
- Ivao Odzima
- Ehtsio Bombardelli
|
RU2137764C1 |
