METHOD FOR PREDICTING MINOR ABNORMALITIES IN THE DEVELOPMENT OF FETAL HEART AT INTRAUTERINE VIRAL INFECTIONING Russian patent published in 2008 - IPC G01N33/48 

FIELD: medicine, obstetrics.

SUBSTANCE: in female peripheral venous blood at intrauterine infectioning, in the second trimester of pregnancy it is necessary to detect the concentration of MMP-1, MMP-3, antibodies to cardiolipin of IgG class, C-reactive protein, CPK Cor CK to calculate discriminant function (Y) by the following formula: Y=125-7.5×A-7.7×B-36.2×C-0.8×D-0.2×E, where A - the value of MMP-1 (ng/mL); B - the value of MMP-3 (ng/mL); C - the value of C-reactive protein (mg/dL); D - the value of antibody to cardiolipin of IgG class (GPL U/ml); E - the value of CPK Cor CK (U/l). In case of Y<0 one should diagnose minor abnormalities in the development of fetal heart at accuracy being 92.0%, specificity being 100%, sensitivity being 85.7%. The innovation provides the chance to carry out complex biochemical trial to diagnose minor abnormalities in the development of fetal heart in case of intrauterine viral infectioning.

EFFECT: higher accuracy of diagnostics.

4 ex, 1 tbl