METHODS FOR SPRAY DRYING FOR PRODUCTION OF SOLID-AMORPHOUS DISPERSIONS OF DRUGS AND POLYMERS Russian patent published in 2008 - IPC A61K9/16 

FIELD: medicine, pharmaceutical composition containing solid-amorphous dispersion of drug and polymer.

SUBSTANCE: claimed method includes a) providing of drier equipped with atomizer, connected with drying chamber, wherein drying chamber has inlet and outlet; b) production of spraying solution by dissolution of poor soluble drug and polymer in solvent; c) spraying of said solution though atomizer to drying chamber to produce drops with average volume of less than 500 mum; d) passing of drying gas through inlet at flow rate and temperature (Tinlet) sufficient to solidify of abovementioned drops and to produce of target dispersion for 20 sec or less; wherein said dispersion provides either increased concentration or accelerated dissolution of abovementioned poor soluble drug in said polymer. Feeding rate of spraying solution is at least 10 kg/h, and Toutlet of drying gas is less then boiling point of said solvent. Drying gas additionally contains said solvent in vapor form.

EFFECT: homogenous solid dispersions with low levels of residual solvent.

13 cl, 5 tbl, 6 dwg, 8 ex