FIELD: chemistry.
SUBSTANCE: invention relates to a sodium salt of formula I compound in the solid amorphous form. The sodium salt of formula (I) compound is obtained by (a) the preparation of a mixture of the formula I compound in a non-aqueous solvent and a water solution of sodium hydroxide; and (b) drying by spraying of the mixture (a) in a spray-drying device. The stage (a) includes mixing the sodium hydroxide solution with the said solvent and further addition of the formula I compound. The solvent is represented by halogen-containing hydrocarbon. The invention also relates to a pharmaceutical composition, possessing HCV inhibiting properties, including sodium salt of the formula I compound in the amorphous form, and a pharmaceutically acceptable carrier.
EFFECT: sodium salt of the formula (I) compound for application as HCV inhibitor and medication for HCV treatment.
10 cl, 7 dwg, 3 ex
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Authors
Dates
2014-12-27—Published
2010-02-26—Filed