AMORPHOUS SALT OF MACROCYCLIC HCV INHIBITOR Russian patent published in 2014 - IPC C07D417/04 A61K31/4709 A61P31/14 

Abstract RU 2536868 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a sodium salt of formula I compound in the solid amorphous form. The sodium salt of formula (I) compound is obtained by (a) the preparation of a mixture of the formula I compound in a non-aqueous solvent and a water solution of sodium hydroxide; and (b) drying by spraying of the mixture (a) in a spray-drying device. The stage (a) includes mixing the sodium hydroxide solution with the said solvent and further addition of the formula I compound. The solvent is represented by halogen-containing hydrocarbon. The invention also relates to a pharmaceutical composition, possessing HCV inhibiting properties, including sodium salt of the formula I compound in the amorphous form, and a pharmaceutically acceptable carrier.

EFFECT: sodium salt of the formula (I) compound for application as HCV inhibitor and medication for HCV treatment.

10 cl, 7 dwg, 3 ex

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RU 2 536 868 C2

Authors

Van Remortere Peter Jozef Marija

Vandekrjujs Roger Petrus Gerebern

De Kok Kherman

Dates

2014-12-27Published

2010-02-26Filed