FIELD: medicine.
SUBSTANCE: invention refers to a method for making slow-release microspheres containing a biodegradable polymer as a carrier and a drug, and to the drug-loaded microspheres made by the specified method. The method provides spraying in the dry chamber of a solution, suspension or emulsion containing the biodegradable polymer, a drug and a solvent, and air-drying of the solvent to prepare the spray-dried microspheres. The prepared microspheres are dispersed in an aqueous solution containing polyvinyl alcohol to remove a residual solvent and to improve the dispersibility of the microspheres, and the dried microspheres are removed from the aqueous solution.
EFFECT: method allows to make microspheres with high effective drug encapsulation without residual toxic solvent and the improved syringe needle permeability.
11 cl, 3 dwg, 5 tbl, 16 ex
