FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to using a powder containing 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile (TMC278) or its stereoisomer form, dispersed in water-soluble polyvinyl pyrrolidone/vinyl acetate to be mixed with water for preparing a drug preparation for treating a HIV patient. Polyvinyl pyrrolidone/vinyl acetate is related to TMC278 as 50:1 to 1:1. The invention refers to a supersaturated solution of TMC278 or its stereoisomer form and water-soluble polyvinyl pyrrolidone/vinyl acetate in an aqueous medium for preparing the drug preparation for treating a HIV patient The invention also concerns a method for preparing said supersaturated solution.
EFFECT: invention aims at providing effective concentrations and improved absorption of the poorly water-soluble active substance TMC278.
15 cl, 5 tbl, 1 dwg, 2 ex
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