PHARMACEUTICAL COMPOSITION POSSESSING ANTI-PROLIFERATIVE EFFECT (VARIANTS), METHOD FOR ITS PREPARING AND METHODS FOR ITS USING Russian patent published in 2008 - IPC A61K31/5377 A61K47/38 A61P35/00

Abstract RU 2318518 C2

FIELD: medicine, pharmacy.

SUBSTANCE: invention proposes a pharmaceutical composition comprising 4-(3¹-chloro-4¹-fluoroanilino)-7-methoxy-6-(3-morpholinopropoxy)quinazoline or its pharmaceutically acceptable salt (agent) and cellulose water-soluble ether, or cellulose water-soluble ester. The composition possesses the anti-proliferative effect. Cellulose ether and ester represented in the composition inhibit the precipitation rate of agent from solution in transport from stomach acid medium to upper regions of digestive tract medium with alkaline pH values that provides improved pharmacokinetic properties of the composition.

EFFECT: improved and valuable medicinal and pharmaceutical properties of composition.

23 cl, 4 dwg, 4 tbl, 14 ex

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RU 2 318 518 C2

Authors

Dzhellert Pol Richard

Parker Majkl Dejvis

De-Matas Marsel

Dates

2008-03-10—Published

2003-02-24—Filed