DERIVATIVES OF CINNAMIC ACID AMIDE Russian patent published in 2008 - IPC C07C235/34 C07C255/54 A61K31/165 A61K31/275 

Abstract RU 2318802 C2

FIELD: organic chemistry, medicine, biochemistry, pharmacy.

SUBSTANCE: invention relates to compound of the formula (I): wherein R1 represents (C1-C3)-alkyl, halogen atom, halogen-(C1-C6)-alkyl, cyano-, (C1-C6)-alkoxy- or halogen-(C1-C6)-alkoxy-group; each among radicals R21, R22, R23 and R24 is chosen independently from group consisting of hydrogen atom and fluorine atom; R3 represents hydrogen atom or (C1-C3)-alkyl; A means bivalent group of the formulae (a): , (b): or (c): R4 represents hydrogen atom or (C1-C3)-alkyl; each radical among R5, R6 and R7 represents independently hydrogen atom or (C1-C6)-alkyl; n = 1, 2 or 3 under condition that 3-[4-(3-chlorobenzoxy)phenyl]-N-ethylpropioneamide and 3-[4-(4-bromobenzyloxy)phenyl]propioneamide are excluded. Also, invention relates to a medicinal agent possessing inhibitory effect with respect to activity of monoaminooxidase B that comprises one or more compounds of the formula (I) and pharmaceutically acceptable excipients. Invention proposes derivatives of cinnamic acid possessing inhibitory effect with respect to activity of monoaminooxidase B.

EFFECT: valuable medicinal and biochemical properties of compounds.

9 cl, 22 ex

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RU 2 318 802 C2

Authors

Kholidon Sinese

Rodriges-Sarm'Ento Rosa Marija

Tomas Ehndr'Ju Uill'Jam

Vostl' Vol'Fgang

Viler Rene

Dates

2008-03-10Published

2003-07-07Filed