FIELD: organic chemistry, medicine, biochemistry, pharmacy.
SUBSTANCE: invention relates to compound of the formula (I): wherein R1 represents (C1-C3)-alkyl, halogen atom, halogen-(C1-C6)-alkyl, cyano-, (C1-C6)-alkoxy- or halogen-(C1-C6)-alkoxy-group; each among radicals R21, R22, R23 and R24 is chosen independently from group consisting of hydrogen atom and fluorine atom; R3 represents hydrogen atom or (C1-C3)-alkyl; A means bivalent group of the formulae (a): , (b): or (c): R4 represents hydrogen atom or (C1-C3)-alkyl; each radical among R5, R6 and R7 represents independently hydrogen atom or (C1-C6)-alkyl; n = 1, 2 or 3 under condition that 3-[4-(3-chlorobenzoxy)phenyl]-N-ethylpropioneamide and 3-[4-(4-bromobenzyloxy)phenyl]propioneamide are excluded. Also, invention relates to a medicinal agent possessing inhibitory effect with respect to activity of monoaminooxidase B that comprises one or more compounds of the formula (I) and pharmaceutically acceptable excipients. Invention proposes derivatives of cinnamic acid possessing inhibitory effect with respect to activity of monoaminooxidase B.
EFFECT: valuable medicinal and biochemical properties of compounds.
9 cl, 22 ex
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Authors
Dates
2008-03-10—Published
2003-07-07—Filed