FIELD: organic chemistry, biochemistry, medicine, pharmacy.
SUBSTANCE: invention relates to novel 2,3-dihydroisoindoles of the formula (I): 
or the formula (II): 
wherein X means -CH=; R1 means -(CH2)n-CO-NR5R6, -(CH2)n-NR5R6, -(CH2)n-COOR7, -(CH2)n-CN, -(CH2)n-isoindol-1,3-dionyl, -(CH2)p-OR; R2 means hydrogen atom (H), (C1-C6)-alkyl, -OH; R3 means H, (C1-C6)-alkyl; R4 means halogen atom, halogen-(C1-C6)-alkyl, (C1-C6)-alkoxy-, halogen -(C1-C6)-alkoxy group; R5 and R6 mean independently of one another H, (C1-C3)-alkyl; R7 means (C1-C6)-alkyl; R8 means H, (C1-C6)-alkyl; m = 1, 2 or 3; n = 0, 1 or 2; p = 1 or 2, and to their pharmaceutically acceptable salts. Proposed compounds possess inhibitory effect on activity of enzyme monoamine oxidase B that allows their using for production of drugs designated for prophylaxis and treatment of diseases mediated by enzyme monoamine oxidase B.
EFFECT: valuable medicinal and biochemical properties of compounds.
19 cl, 4 sch, 34 ex
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