FIELD: organic chemistry, medicine, cardiology.
SUBSTANCE: invention describes compounds of the formula (I): 
wherein R1 and R2 mean hydrogen atom (H), alkyl, fluorine (F), chlorine (Cl), bromine (Br) atom, alkoxy-group, -S(O)nR7, polyfluoroalkyl, polyfluoroalkoxy-group; R3 means Alk-R8, cycloalkyl; R8 means H, cycloalkyl, polyfluoroalkyl, phenyl or -OH; R4, R5 and R6 mean H or alkyl; R7 means alkyl. Also, invention relates to a method for synthesis of these compounds and a pharmaceutical composition possessing inhibitory activity with respect to Na+/K+ cellular exchange. Proposed compounds are suitable as anti-arrhythmic medicinal agents with a cardioprotective component used in prophylaxis of infarction and treatment of infarction and treatment of stenocardia. Compounds inhibit also pathophysiological process by prophylactic effect associated with development of disorders induced by ischemia, in particular, arising ischemia-induced cardiac arrhythmia and cardiac insufficiency.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
17 cl, 59 ex
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