ISOINDOLINE COMPOUNDS USED FOR TREATING CANCER Russian patent published in 2014 - IPC C07D401/04 C07D401/14 C07D405/14 C07D413/14 C07D417/14 A61K31/454 A61K31/5377 A61K31/496 A61K31/473 A61P35/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to isoindoline compounds, such as compounds of Formula or to their pharmaceutically acceptable salts or stereoisomers, wherein X represents CH₂; Y represents O, cyanamido (N-C≡N) or amido (NH); m represents an integer of 0 or 1; R¹ represents hydrogen or C_1-6 alkyl; R² represents hydrogen, C_1-10 alkyl, C_0-6alkyl-(5-10-merous heteroaryl containing one, two or three heteroatoms independently specified in O, S or N), C_0-6alkyl-(6-merous heterocyclyl which represents morpholinyl or piperazinyl), C_0-6alkyl-OH, -NHCO-C_1-6alkyl, -OR²¹ or - (CH₂-Z)-(6-merous heteroaryl which represents pyridinyl), wherein each heteroaryl and heterocyclyl is optionally substituted by one or more C_1-6 alkyls; R³ represents hydrogen, halogen, -NO₂, C_0-6alkyl-OH, C_0-4 alkyl-NH₂ or -OR²¹; R²¹ represents phenyl, pyridinyl, piperidinyl or -CO(CH₂)R²²; R²² represents -NH₂ or piperazinyl; and Z represents O; provided R¹ represents hydrogen, then R² is other than hydrogen or C_1-10alkyl; provided R³ represents halogen, then R² represents C_0-6alkyl-(5-6-merous heterocyclyl). The invention also refers to pharmaceutical compositions for controlling angiogenesis or inhibiting the TNFα production on the basis of the above compounds.

EFFECT: there are prepared new compounds and compositions based thereon to be used in medicine for treating or preventing a disease or a disorder, such as cancer, pain skin diseases, lung disorders, parasitic diseases, immunodeficiency disorders, CNS disorders, CNS injuries, atherosclerosis or associated disorders, sleep disorders or associated disorders.

26 cl, 68 ex