ANTHRANILIC ACID AMIDES, METHOD FOR THEIR PREPARING AND THEIR USING, METHOD FOR TREATMENT OF NEOPLASM DISEASE AMD PHARMACEUTICAL DRUG POSSESSING INHIBITORY ACTIVITY WITH RESPECT TO TYROSINE KINASE VEGF RECEPTOR Russian patent published in 2008 - IPC C07D213/64 C07D213/70 A61K31/44 A61P35/00

Abstract RU 2318811 C2

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to anthranilic acid amides of the formula (I): wherein R₁ means hydrogen atom or (lower)-alkyl; R₂ means hydrogen atom or (lower)-alkyl; R₃ means perfluoro-(lower)-alkyl; X means oxygen atom or sulfur atom, or to its N-oxide or tautomer, to salts of such anthranilic acid amides, their N-oxides or their tautomers. Compounds of the formula (I) possess inhibitory activity with respect to tyrosine kinase VEGF receptors and can be used in treatment of neoplasm, retinopathy or age degeneration resulting to appearance of spots in retina in humans or mammals. Also, invention relates to using anthranilic acid amide of the formula (I) for preparing a pharmaceutical drug possessing above said activity, to a method for treatment of neoplasm disease, a pharmaceutical drug and a method for synthesis of anthranilic acid amide of the formula (I).

EFFECT: improved method of synthesis, valuable medicinal properties of compounds and pharmaceutical drug.

9 cl, 7 ex

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RU 2 318 811 C2

Authors

Bol'D Guido

Fjure Paskal'

Manli Pol Uill'Jam

Dates

2008-03-10—Published

2002-11-07—Filed