FIELD: organic chemistry, biochemistry, medicine.
SUBSTANCE: invention relates to derivatives of 2-aminonicotine amide of the formula (I): 
, to methods of their synthesis and a pharmaceutical composition based on thereof inhibiting activity of receptor tyrosine kinase vessel endothelial growth factor (VEGF) and to corresponding method for inhibition of activity of VEGF-receptor tyrosine kinase. It is suggested that this activity will allow offering the curative effect in proliferative diseases associated with angiogenesis, in particular, in treatment of tumors, retinopathy or age degeneration of yellow (corneal) spot.
EFFECT: valuable medicinal properties of compounds and pharmaceutical composition.
9 cl, 42 ex
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