FIELD: biotechnology, in particular gene engineering.
SUBSTANCE: Gene of B9R protein having high homology with extracellular segment of interferon-gamma receptor is isolated by PCR method from Mankeypox virus genome of strain Zaire-96-1-16. Then said protein is cloned in donor plasmid pFastbAC and via site-specific transposition recombinant bacmid is constructed. Said bacmid is used for pest cell transfection to generate target strain.
EFFECT: new drugs for treatment of human diseases associated with hyperproduction of interferon-gamma.
2 cl, 3 dwg, 6 ex
| Title |
Year |
Author |
Number |
| RECOMBINANT PLASMID pFastBAC-B17R DNA CONTAINING COWPOX VIRUS GENOME FRAGMENT CODING ALPHA/BETA-INTERFERON BINDING PROTEIN AND BvB17RG BACULOVIRUS STRAIN PRODUCING SOLUBLE ALPHA/BETA-INTERFERON BINDING PROTEIN OF COWPOX VIRUS |
2009 |
- Gileva Irina Pavlovna
- Nepomnjashchikh Tat'Jana Sergeevna
- Rjazankin Igor' Aleksandrovich
- Shatrova Natal'Ja Mikhajlovna
- Shchelkunova Galina Aleksandrovna
- Shchelkunov Sergej Nikolaevich
|
RU2405824C1 |
| RECOMBINANT PLASMID DNA PFASTBAC-G2R COMPRISING SMALLPOX VIRUS GENOME FRAGMENT ENCODING PROTEIN-ANALOG OF TUMOR NECROSIS FACTOR RECEPTOR AND STRAIN OF BACULOVIRUS BTRI67 PRODUCING SOLUBLE RECEPTOR OF SMALLPOX VIRUS TUMOR NECROSIS FACTOR |
2002 |
- Gileva I.P.
- Shchelkunov S.N.
- Rjazankin I.A.
- Maksjutov Z.A.
- Totmenin A.V.
- Nesterov A.E.
- Ageenko V.A.
|
RU2241754C2 |
| RECOMBINANT PLASMID DNA pFastBac-G2R-IgG, WHICH CONTAINS FRAGMENT OF SMALLPOX VIRUS GENOME, CODING FACTOR OF TUMOUR NECROSIS, BINDING PROTEIN, AND FRAGMENT OF HUMAN GENOME, CODING SECTION OF HEAVY CHAIN OF ANTIBODY G, AND STRAIN OF BACULOVIRUS BvG2RIgG, WHICH PRODUCES SOLUBLE CHIMERIC PROTEIN, WHICH CONSISTS OF SMALLPOX VIRUS PROTEIN, BINDING FACTOR OF TUMOUR NECROSIS, AND FRAGMENT OF HEAVY CHAIN OF HUMAN ANTIBODY G |
2008 |
- Nepomnjashchikh Tat'Jana Sergeevna
- Gileva Irina Pavlovna
- Lebedev Leonid Rudol'Fovich
- Shchelkunov Sergej Nikolaevich
|
RU2376375C2 |
| RECOMBINANT PLASMID DNA pQE-60-TNFR-CrmB-Ind-67 AND pFastBac1-G2R-dSECRET CONTAINING SMALLPOX VIRUS GENOME FRAGMENT CODING TUMOUR NECROSIS FACTOR BINDING CrmB PROTEIN DOMAIN AND Bv/G2R-dSECRET BACULOVIRUS DOMAIN PRODUCING SECRETING TNF-BINDING CrmB PROTEIN OF SMALLPOX VIRUS WITH DELETED SECRET DOMAIN |
2011 |
- Tregubchak Tat'Jana Vladimirovna
- Nepomnjashchikh Tat'Jana Sergeevna
- Antonets Denis Viktorovich
- Shchelkunov Sergej Nikolaevich
|
RU2471869C1 |
| VIRAL GENOME FRAGMENT OF CHICKEN K STRAIN VARIOLA WHICH CONTAINS THYMIDINE KINASE GENE, pTK1FPV AND pTK2FPV RECOMBINANT PLASMID DNAs WHICH CONTAIN THIS SEQUENCE, AND pINTFPV1 RECOMBINANT PLASMID DNA WHICH IS ABLE TO INTEGRATE INTO VIRAL GENOME OF CHICKEN VARIOLA |
1999 |
- Susloparov M.A.
- Pljasunov I.V.
- Bakhtina M.M.
- Susloparov I.M.
- Makhova N.M.
- Lokteva L.A.
|
RU2180352C2 |
| PICHIA PASTORIS YEAST STRAIN - PRODUCER OF CHICKEN INTERFERON-GAMMA, RECOMBINANT PLASMID DNA WHICH FACILITATES BIOSYNTHESIS CHICKEN INTERFERON-GAMMA, AND CONSTRUCTION METHOD THEREOF |
2006 |
- Padkina Marina Vladimirovna
- Gradoboeva Anastasija Evgen'Evna
- Sambuk Elena Viktorovna
- Smirnov Mikhail Nikolaevich
|
RU2386694C2 |
| DNA S54 FRAGMENT ENCODING POLYPEPTIDE SHOWING ACTIVITY OF GAMMA-INTERFERON, RECOMBINANT PLASMID DNA PROVIDING THE SYNTHESIS OF POLYPEPTIDE WITH ACTIVITY OF GAMMA-INTERFERON, AND THE STRAIN OF ESCHERICHIA COLI - A PRODUCER OF POLYPEPTIDE WITH GAMMA-INTERFERON ACTIVITY |
1992 |
- Tat'Kov S.I.
- Smirnova O.Ju.
- Kishchenko G.P.
- Petrenko V.A.
|
RU2046144C1 |
| RECOMBINANT PLASMID DNA PET21-NPVE CONTAINING NUCLEOLOPROTEIN (NP) GENE OF EBOLA VIRUS AND RECOMBINANT PROTEIN NP-VE, OBTAINED AS RESULT OF EXPRESSION OF NP GENE OF EBOLA VIRUS USING RECOMBINANT PLASMID DNA PET21-NPVE AND POSSESSING IMMUNOGENIC AND ANTIGENIC PROPERTIES |
2020 |
- Ivanova Alla Vladimirovna
- Volkova Natalya Vyacheslavovna
- Chepurnov Aleksandr Alekseevich
- Demina Anna Vladimirovna
- Kononova Yuliya Vladimirovna
- Shcherbakov Dmitrij Nikolaevich
- Kazachinskaya Elena Ivanovna
|
RU2739505C1 |
| RECOMBITANT PLASMID DNA pET21-VP40VE CONTAINING THE GENE FOR THE MATRIX PROTEIN VP40 OF EBOLA VIRUS AND THE RECOMBITANT PROTEIN VP40-VE OBTAINED AS A RESULT OF THE GENE EXPRESSION FOR THE PROTEIN VP40 OF EBOLA VIRUS USING THE RECOMBITANT PLASMID DNA pET21-VP40VE AND EXHIBITING IMMUNOGENIC AND ANTIGENIC PROPERTIES |
2020 |
- Ivanova Alla Vladimirovna
- Volkova Natalya Vyacheslavovna
- Chepurnov Aleksandr Alekseevich
- Demina Anna Vladimirovna
- Kononova Yuliya Vladimirovna
- Shcherbakov Dmitrij Nikolaevich
- Kazachinskaya Elena Ivanovna
|
RU2742511C1 |
| RECOMBINANT PLASMID pBi121-ESAT6-CFP10-gIFN, CODING PROTEINS ESAT6 AND CFP10 MYCOBACTERIUM TUBERCULOSIS AND HUMAN GAMMA-INTERFERON IN TRANSGENIC PLANTS |
2011 |
- Tat'Kov Sergej Ivanovich
- Dejneko Elena Viktorovna
- Belavin Pavel Aleksandrovich
- Zagorskaja Alla Alekseevna
- Filipenko Elena Anatol'Evna
- Uvarova Elena Aleksandrovna
- Kakimzhanova Almagul' Apsalamovna
- Ramankulov Erlan Mirkhajdarovich
|
RU2468082C1 |
