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2 471 869

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IPC

C12N15/62(2006-01-01)

C12N15/28(2006-01-01)

C12N15/39(2006-01-01)

C12N15/86(2006-01-01)

C12N7/01(2006-01-01)

A61K38/16(2006-01-01)

(21) (22)

Application

2011118764/10, 2011-05-10

(24)

Start date

2011-05-10

(22)

Actual filing date

2011-05-10

(45)

Published

2013-01-10

(72)

Inventor

Tregubchak Tat'Jana VladimirovnaNepomnjashchikh Tat'Jana SergeevnaAntonets Denis ViktorovichShchelkunov Sergej Nikolaevich

(73)

Holder

Federal'Noe Bjudzhetnoe Uchrezhdenie Nauki Nauchnyj Tsentr Virusologii I Biotekhnologii Gnts Vb

RECOMBINANT PLASMID DNA pQE-60-TNFR-CrmB-Ind-67 AND pFastBac1-G2R-dSECRET CONTAINING SMALLPOX VIRUS GENOME FRAGMENT CODING TUMOUR NECROSIS FACTOR BINDING CrmB PROTEIN DOMAIN AND Bv/G2R-dSECRET BACULOVIRUS DOMAIN PRODUCING SECRETING TNF-BINDING CrmB PROTEIN OF SMALLPOX VIRUS WITH DELETED SECRET DOMAIN Russian patent published in 2013 - IPC C12N15/62 C12N15/28 C12N15/39 C12N15/86 C12N7/01 A61K38/16

Abstract RU 2471869 C1

FIELD: medicine.

SUBSTANCE: there are presented two recombinant plasmid DNA pFastBac 1 -G2R-dSECRET and pQE-60-TNFR-CrmB-Ind-67 coding TNF-binding CrmB protein domain. Said recombinant plasmid DNA pQE-60-TNFR-CrmB-Ind-67 is designed for transformation in cells of the strain E.coli SG13009[pRep4] - a producer of TNF-binding CrmB BHO protein domain.

EFFECT: presented group of inventions is applicable for preparing drugs used in therapy of severe human diseases caused by hyperproduction of tumour necrosis factor and may be used in medicine.

3 cl, 3 dwg, 12 ex

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RU 2 471 869 C1

Authors

Tregubchak Tat'Jana Vladimirovna

Nepomnjashchikh Tat'Jana Sergeevna

Antonets Denis Viktorovich

Shchelkunov Sergej Nikolaevich

Dates

2013-01-10—Published

2011-05-10—Filed